Why the study?
Sex differences in hemodynamic responses to hypovolemia remain an open question.
Does lower body negative pressure induce sex-specific hemodynamic changes in upper and lower limbs as measured by NIRS?
Population
28 subjects in a supine position
Comparison
Randomized 90 s LBNP levels (-10, -20, -30, -40 mmHg) and 5 min at -30 mmHg between sexes
Design
Randomized physiological crossover study
Authors
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Females show reduced vasoconstriction versus males during LBNP; NIRS findings leave open clinical relevance and need for larger trials.
Does lower body negative pressure induce sex-specific hemodynamic changes in upper and lower limbs as measured by NIRS?
NIRS monitoring during lower body negative pressure reveals stronger vasoconstrictive responses in males compared to females, and in lower limbs compared to upper limbs.
Allois et al. (2025) studied this question.
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