What question did this study set out to answer?

To determine the impact of lower body negative pressure on subcutaneous blood flow and the local veno-arteriolar reflex in the human forearm.

February 1, 1981Acta Physiologica Scandinavica

Effect of lower body negative pressure upon local regulation of blood flow in human subcutaneous tissue

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Why the study?

Does lower body negative pressure affect local regulation of subcutaneous blood flow in young healthy males?

Population

7 young healthy male subjects in supine position

Design

Other

Authors

KSKnud SkagenOslo University Hospital OHO. HenriksenCopenhagen University Hospital FBF. Bonde-PetersenUniversity of Copenhagen

Discussion

Member takes

Implication

Central sympathetic vasoconstriction overrides local reflexes in subcutaneous tissue; leaves open relevance to clinical populations or disease states.

Key Points

To determine the impact of lower body negative pressure on subcutaneous blood flow and the local veno-arteriolar reflex in the human forearm.
Studied 7 young healthy male subjects in the supine position exposed to lower body negative pressure (LBNP) of -40 mmHg and -60 mmHg.
Measured subcutaneous forearm blood flow using the local 133Xe washout technique under baseline conditions and during proximal nervous blockade.
Assessed the local veno-arteriolar reflex by inducing an increase in venous transmural pressure via arm lowering during LBNP.
Application of -40 mmHg and -60 mmHg LBNP decreased forearm 133Xe washout rates by 34% and 50%, respectively.
Proximal nervous blockade abolished the LBNP-induced vasoconstriction, demonstrating mediation by a central sympathetic reflex mechanism.
The veno-arteriolar reflex response to arm lowering was absent during -40 mmHg LBNP but was restored following proximal nervous blockade.

Structured PICO

Does lower body negative pressure affect local regulation of subcutaneous blood flow in young healthy males?

Population

7 young healthy male subjects in supine position

Intervention

Lower body negative pressure (LBNP) of -40 and -60 mmHg

Outcome

Subcutaneous blood flow in the forearm measured by local 133Xe washout techniquesurrogate

Lower body negative pressure induces a centrally mediated sympathetic reflex vasoconstriction in human subcutaneous tissue, overriding local veno-arteriolar reflexes.

Cite This Study

Skagen et al. (1981) studied this question.

synapsesocial.com/papers/6a83f993f72f0ca72062d34c https://doi.org/10.1111/j.1748-1716.1981.tb06713.x

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Implication

Central sympathetic vasoconstriction overrides local reflexes in subcutaneous tissue; leaves open relevance to clinical populations or disease states.

Effect of lower body negative pressure upon local regulation of blood flow in human subcutaneous tissue

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Effect of lower body negative pressure upon local regulation of blood flow in human subcutaneous tissue

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider