May 1, 1998Hypertension

Role of Nitric Oxide in Adenosine-Induced Vasodilation in Humans

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Why the study?

Does nitric oxide mediate adenosine-induced vasodilation in the human forearm?

Population

Humans (n=6)

Comparison

Intrabrachial adenosine infusion during… vs Intrabrachial adenosine infusion during…

Design

Other

Authors

FCFernando CostaAmerican Heart Association IBItalo BiaggioniGeneral Cardiology

Discussion

Member takes

Implication

Adenosine vasodilation appears NO-independent in forearm; hypothesis-generating for vascular mechanisms in hypertension.

Structured PICO

Does nitric oxide mediate adenosine-induced vasodilation in the human forearm?

Population

Humans (n=6)

Intervention

Intrabrachial adenosine infusion (125 microg/min) during intrabrachial infusion of the nitric oxide synthase inhibitor NG-monomethyl-L-arginine (L-NMMA) (12.5 mg/min)

Comparator

Intrabrachial adenosine infusion (125 microg/min) during intrabrachial infusion of saline

Outcome

Forearm blood flow response assessed with venous occlusion plethysmographysurrogate

Adenosine-induced vasodilation in the human forearm is not mediated by nitric oxide.

Cite This Study

Costa et al. (1998) studied this question.

synapsesocial.com/papers/6a829fac4c27fb5db08ad68b https://doi.org/10.1161/01.hyp.31.5.1061

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Role of Nitric Oxide in Adenosine-Induced Vasodilation in Humans

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Role of Nitric Oxide in Adenosine-Induced Vasodilation in Humans

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider