Impact of Blood Pressure Control on Cardiovascular Events in 26,512 Japanese Hypertensive Patients: The Japan Hypertension Evaluation with Angiotensin II Antagonist Losartan Therapy (J-HEALTH) Study, a Prospective Nationwide Observational Study
Why the study?
Does blood pressure control below 140/90 mmHg with losartan reduce cardiovascular events in Japanese hypertensive patients?
Population
26,512 Japanese hypertensive patients, mean age 62.2 years, 43.9% men.
Design
Cohort, open-labelled
Follow-up
mean 3.0 years
Authors
Discussion
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Implication
Supports BP <140/90 mmHg target on losartan in Japanese hypertensives; observational data leave causality and generalizability open.
Structured PICO
Does blood pressure control below 140/90 mmHg with losartan reduce cardiovascular events in Japanese hypertensive patients?
P
Population
26,512 Japanese hypertensive patients, mean age 62.2 years, 43.9% men.
I
Intervention
Open-labelled losartan for a maximum of 5 years.
O
Outcome
Stroke, myocardial infarction (MI) including sudden cardiac death, and all cardiovascular (CV) events (stroke and MI).hard clinical
Achieving a blood pressure below 140/90 mmHg during losartan therapy is associated with a reduced risk of cardiovascular events in Japanese hypertensive patients, including the very elderly.
Cite This Study
Shimamoto et al. (2008) studied this question.