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May 4, 2007Cardiovascular Research

Activation of PPARδ inhibits cardiac fibroblast proliferation and the transdifferentiation into myofibroblasts

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Why the study?

Does activation of PPARdelta inhibit cardiac fibroblast proliferation and transdifferentiation into myofibroblasts?

Population

Cardiac fibroblasts (CF) and myofibroblasts (CMF)

Comparison

PPARdelta ligand GW501516 or adenoviral… vs PPARalpha ligand Wy-14,643, PPARgamma ligand…

Design

Preclinical

Authors

BTBirgit E.J. TeunissenMaastricht UniversityPSPeter SmeetsGhent University HospitalPWPeter WillemsenWageningen University & Research

Discussion

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Implication

Positions PPARdelta as antifibrotic target in fibroblasts; leaves open in vivo efficacy and clinical translation.

Structured PICO

Does activation of PPARdelta inhibit cardiac fibroblast proliferation and transdifferentiation into myofibroblasts?

P
Population
Cardiac fibroblasts (CF) and myofibroblasts (CMF)
I
Intervention
PPARdelta ligand GW501516 or adenoviral overexpression of PPARdelta
C
Comparator
PPARalpha ligand Wy-14,643, PPARgamma ligand rosiglitazone, or control
O
Outcome
Cardiac fibroblast proliferation, fibroblast to myofibroblast transdifferentiation, and collagen synthesissurrogate

Activation of PPARdelta reduces cardiac fibroblast proliferation, transdifferentiation, and collagen synthesis, suggesting it as a potential molecular target for attenuating cardiac fibrosis.

Cite This Study

Teunissen et al. (2007) studied this question.

synapsesocial.com/papers/6a82a1671d8eddfbf50f6a26https://doi.org/10.1016/j.cardiores.2007.04.026
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Peroxisome Proliferator-Activated Receptor (PPAR) α and PPARβ/δ, but not PPARγ, Modulate the Expression of Genes Involved in Cardiac Lipid Metabolism2003 · 403 citations
  2. 2Peroxisome Proliferator-Activated Receptor-α and Receptor-γ Activators Prevent Cardiac Fibrosis in Mineralocorticoid-Dependent Hypertension2003 · 146 citations
  3. 3Transcriptional activation of the cardiac myosin light chain 2 and atrial natriuretic factor genes by protein kinase C in neonatal rat ventricular myocytes.1992 · 169 citations
  4. 4Mechanical force regulation of myofibroblast differentiation in cardiac fibroblasts2003 · 270 citations
  5. 5Are Myocardial Fibrosis and Diastolic Dysfunction Reversible in Hypertensive Heart Disease?2005 · 27 citations