May 11, 2011EP EuropaceOpen Access

Pharmacological cardioversion of atrial fibrillation--a double-blind, randomized, placebo-controlled, multicentre, dose-escalation study of AZD1305 given intravenously

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Why the study?

Does AZD1305 intravenous infusion improve conversion to sinus rhythm in patients with atrial fibrillation?

Population

n=171 patients with atrial fibrillation episodes of duration 3 h to 3 months

Comparison

AZD1305 intravenous infusion at ascending dose… vs Matching placebo intravenous infusion

Design

RCT, randomized in a 3:1 ratio, double-blind

Follow-up

90 min

Authors

ARA RónaszékiSemmelweis University MAMarco AlingsElectrophysiology KEKenneth EgstrupCardiac Imaging

Discussion

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Implication

AZD1305 shows dose-dependent AF conversion efficacy; QT-related safety risks halted development and caution similar agents.

Structured PICO

Does AZD1305 intravenous infusion improve conversion to sinus rhythm in patients with atrial fibrillation?

Population

n=171 patients with atrial fibrillation episodes of duration 3 h to 3 months

Intervention

AZD1305 intravenous infusion (maximum 30 min) at ascending dose rates of 50, 100, 130, and 180 mg/h

Comparator

Matching placebo intravenous infusion (maximum 30 min)

Outcome

Proportion of patients converting to sinus rhythm within 90 min of the start of infusionsurrogate

Although AZD1305 effectively converted atrial fibrillation to sinus rhythm in a dose-dependent manner, its development was discontinued due to an unfavorable safety profile including QT prolongation and torsade de pointes.

Cite This Study

Rónaszéki et al. (2011) studied this question.

synapsesocial.com/papers/6a82a1add15458f571d10ea8 https://doi.org/10.1093/europace/eur120

Topics

Persistent AF management Atrial fibrillation Anticoagulation in AF AF ablation outcomes

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Pharmacological cardioversion of atrial fibrillation--a double-blind, randomized, placebo-controlled, multicentre, dose-escalation study of AZD1305 given intravenously

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Pharmacological cardioversion of atrial fibrillation--a double-blind, randomized, placebo-controlled, multicentre, dose-escalation study of AZD1305 given intravenously

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

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