What question did this study set out to answer?

To determine whether partial arterial constriction induces endothelial damage and thrombosis independently of substantial changes in blood flow rate.

March 1, 1981CirculationOpen Access

Endothelial cell damage and thrombus formation after partial arterial constriction: relevance to the role of coronary artery spasm in the pathogenesis of myocardial infarction.

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Why the study?

Does partial arterial constriction cause endothelial damage and thrombus formation in animal models?

Population

4 dogs (left anterior descending coronary artery) and 15 rabbits (right common carotid artery)

Comparison

40-60% reduction in transluminal diameter for 1… vs Control studies with a second ligature placed…

Design

Preclinical

Follow-up

1 hour

Authors

SGS. David GertzHebrew University of Jerusalem GUG Uretsky RWRebecka WajnbergIsrael Ministry of Health

Discussion

Member takes

Implication

Focal constriction may induce endothelial damage and microthrombi independent of flow; leaves open relevance to coronary spasm in MI.

Key Points

To determine whether partial arterial constriction induces endothelial damage and thrombosis independently of substantial changes in blood flow rate.
Partial ligation producing a 40-60% diameter constriction was maintained for 1 hour in the left anterior descending coronary artery of 4 dogs and the right common carotid artery of 15 rabbits.
Luminal endothelial morphology was examined using scanning electron microscopy, and hemodynamics were monitored with an electromagnetic flow probe.
In control experiments (n=14), a second proximal ligature was applied before the first to substantially or completely reduce blood flow to the distal constriction site.
Partial constriction resulted in endothelial craters, ballooning, fragmentation, desquamation, and platelet adhesion forming microthrombi at the constriction site despite virtually unchanged blood flow.
In flow-restricted controls, endothelial desquamation occurred in only 1 of 14 animals, with significantly fewer craters and balloons.

Structured PICO

Does partial arterial constriction cause endothelial damage and thrombus formation in animal models?

Population

4 dogs (left anterior descending coronary artery) and 15 rabbits (right common carotid artery)

Intervention

40-60% reduction in transluminal diameter for 1 hour by partial ligation with suture thread

Comparator

Control studies with a second ligature placed proximal to and before the first to reduce blood flow substantially or totally (n=14)

Outcome

Endothelial cell damage (craters, balloons, fragmentation, desquamation) and thrombus formation (platelet attachment, microthrombi) assessed by scanning electron microscopysurrogate

Endothelial damage and thrombus formation may occur at the site of focal arterial constriction even when the reduction in transluminal diameter is insufficient to alter substantially the rate of flow, which may be relevant to coronary artery spasm in myocardial infarction.

Cite This Study

Gertz et al. (1981) studied this question.

synapsesocial.com/papers/6a82a42213f69a4ecb1e0a0a https://doi.org/10.1161/01.cir.63.3.476

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Endothelial cell damage and thrombus formation after partial arterial constriction: relevance to the role of coronary artery spasm in the pathogenesis of myocardial infarction.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Endothelial cell damage and thrombus formation after partial arterial constriction: relevance to the role of coronary artery spasm in the pathogenesis of myocardial infarction.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider