Key result
PEGME homogeneous HDL-C assay demonstrates superior specificity and accuracy compared to PPD.
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We report on the performance of four HDL-cholesterol assays: a homogeneous method based on polyethylene glycol-modified enzymes/alpha-cyclodextrin sulfate (PEGME; Kyowa); a homogeneous method based on polyanion-polymer/detergent (PPD; Daiichi); the usual precipitation method with phosphotungstic acid/MgCl2 (PTA); and an ultracentrifugation (UC) procedure. The homogeneous HDL-cholesterol assays (performed with automated analyzers) were precise and correlated well with the PTA and UC assays. The specificity and accuracy of the PEGME method were better than those of the PPD method.
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Arranz-Peña et al. (1998) studied this question. Homogeneous HDL-cholesterol assays (PEGME and PPD) vs. Precipitation (PTA) and ultracentrifugation (UC) methods was evaluated on Analytical performance (precision, correlation, specificity, and accuracy) of HDL-cholesterol measurement. Homogeneous HDL-cholesterol assays (PEGME and PPD) correlated well with precipitation and ultracentrifugation methods, with PEGME showing superior specificity and accuracy over PPD.
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