Why the study?
Does rutin prevent pirarubicin-induced cardiac toxicity in a rat model?
Does rutin prevent pirarubicin-induced cardiac toxicity in a rat model?
Rutin demonstrates antioxidant and anti-apoptotic properties that attenuate pirarubicin-induced cardiac toxicity in a preclinical rat model.
Supports rutin's anti-apoptotic effects in rat pirarubicin cardiotoxicity; hypothesis-generating for clinical translation.
We established both an acute and chronic cardiac toxicity rat model, which showed pretreatment with rutin attenuated pirarubicin-induced myocardial histopathological injury, electrocardiogram abnormalities, and cardiac dysfunction. Rutin also significantly reduced serum levels of MDA, BNP, CK-MB, CTnT, and LDH and increased serum SOD levels. Treatment with rutin and dexrazoxane resulted in an increase in Bcl-2/Bax ratio (p < 0.05) and reduction in JNK and Caspase-3 protein levels, compared to the pirarubicin group (all p < 0.05). Furthermore, rutin at a dose of 50 mg/kg significantly attenuated the above-mentioned alterations. Our study suggests the antioxidant and anti-apoptotic properties of rutin may be responsible for the cardioprotective effects observed.
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Wang et al. (2017) studied this question.
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