Why the study?
Does increased AT1 signaling in podocytes induce glomerulosclerosis in a transgenic rat model?
Does increased AT1 signaling in podocytes induce glomerulosclerosis in a transgenic rat model?
Increased AT1 signaling in podocytes directly leads to protein leakage and structural damage progressing to focal segmental glomerulosclerosis in a transgenic rat model.
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Podocyte AT1 signaling drives FSGS in this model; extends mechanistic insights but leaves open human therapeutic translation.
Hoffmann et al. (2004) studied this question.
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