Why the study?
Does chronic ACE-inhibitor treatment induce functional kinin B1- and B2-receptor expression in normotensive rats and mice?
Population
Normotensive rats and B2-receptor knockout mice
Comparison
Chronic ACE-inhibitor treatment for 6 weeks vs Control (implied)
Design
Preclinical
Follow-up
6 weeks
Authors
Loading...
Should not change practice; leaves open B1-receptor role in human ACE-inhibitor effects.
Does chronic ACE-inhibitor treatment induce functional kinin B1- and B2-receptor expression in normotensive rats and mice?
Chronic ACE-inhibitor administration induces functional vascular and renal B1-receptor expression, contributing to its hypotensive and potentially renoprotective effects.
Marin‐Castaño et al. (2002) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: