Population
11 wild-type mice and 13 genetically engineered mice with deleted B receptor gene, and rat vascular smooth…
Comparison
Angiotensin II infusion in vivo, and ANG II… vs Baseline/absence of ANG II, and presence vs…
Design
Preclinical
Follow-up
3 days (in vivo) and up to 24 hours (in vitro)
Authors
Loading...
Does not support clinical changes in RAAS therapy; leaves open AT1-bradykinin receptor crosstalk in human disease.
Excess angiotensin II upregulates the expression of bradykinin B2 receptors, and in their absence, further upregulates B1 receptors via an AT1-mediated pathway.
Kintsurashvili et al. (2001) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: