Population
Wistar rats
Comparison
Adriamycin treatment vs Control rats
Design
Preclinical
Authors
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Oxidative stress may link to autonomic changes in this rat diastolic dysfunction model; leaves open translation to human HFpEF.
In a rat model, adriamycin-induced diastolic dysfunction is associated with increased oxidative stress, which correlates with reduced reflex control of circulation despite preserved overall baroreflex sensitivity.
Rabelo et al. (2001) studied this question.
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