Elevated plasma angiotensin converting enzyme 2 activity is an independent predictor of major adverse cardiac events in patients with obstructive coronary artery disease

79 patients with obstructive coronary artery disease (defined as ≥50% stenosis of the left main coronary artery and/or ≥70% stenosis in ≥ 1 other major epicardial vessel on invasive coronary angiography)

Elevated plasma ACE2 activity (above-median or log-transformed)

Lower plasma ACE2 activity (below-median)

Major adverse cardiovascular events (MACE), defined as a composite of cardiovascular mortality, heart failure, or myocardial infarctioncomposite