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January 1, 2001Thrombosis and Haemostasis

Hepatic Thrombopoietin mRNA Is Increased in Acute Inflammation

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Implication

Hepatic TPO mRNA upregulation may drive reactive thrombocytosis in inflammation; leaves open translation to human disease or therapy.

Key Points

Key points are not available for this paper at this time.

Cite This Study

A 2001 study studied this question.

synapsesocial.com/papers/6a82a919d88fdfcf4fa0c61c https://doi.org/10.1055/s-0037-1616745

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Interleukin-6 Increases Thrombopoietin Production in Human Hepatoma Cells HepG2 and Hep3B2000 · 80 citations
2Localization and Regulation of Thrombopoietin mRNA Expression in Human Kidney, Liver, Bone Marrow, and Spleen Using In Situ Hybridization1997 · 292 citations
3The reciprocal relationship of thrombopoietin (c-Mpl ligand) to changes in the platelet mass during busulfan-induced thrombocytopenia in the rabbit1995 · 397 citations
4Serum thrombopoietin and interleukin 6 concentrations in tumour patients and response to chemotherapy‐induced thrombocytopenia1997 · 37 citations
5Expression of hepatic thrombopoietin mRNA in primary cultured hepatocytes and in rats with acute liver injury or bone marrow suppression with or without cirrhosis2000 · 13 citations