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November 1, 1978Scandinavian Journal of Haematology

Occurrence of Megakaryocytes in Various Vessels and Their Retention in the Pulmonary Capillaries in Man

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Population

17 patients with hypertension undergoing renal vein or adrenal vein catheterization

Design

Cross-sectional

Authors

NPNiels Tinggaård PedersenUniversity of Copenhagen

Discussion

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Overview

Supports pulmonary platelet release in normal physiology; leaves open clinical relevance for thrombocytopenia pending prospective validation.

Structured PICO

P
Population
17 patients with hypertension undergoing renal vein or adrenal vein catheterization
O
Outcome
Number and morphology of megakaryocytes in blood from the inferior vena cava, the femoral artery, and a cubital veinsurrogate

This physiological study demonstrates that megakaryocytes release platelets primarily in central venous blood and the pulmonary circulation, where their nuclei are subsequently destroyed.

Cite This Study

Niels Tinggaård Pedersen (1978) studied this question.

synapsesocial.com/papers/6a82aa2d2403b1e95c46fc4fhttps://doi.org/10.1111/j.1600-0609.1978.tb00381.x

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Megakaryocytes and Platelets in Central Venous and Arterial Blood2009 · 61 citations
  2. 2Megakaryocytes in the Pulmonary Circulation1963 · 64 citations
  3. 3Circulating Megakaryocytes and Platelet Release in the Lung1965 · 207 citations
  4. 4Quantitative Observations of Circulating Megakaryocytes in the Blood of Patients with Cancer1964 · 48 citations
  5. 5Circulating Megakaryocytes in Blood from the Antecubital Vein in Healthy, Adult Humans1978 · 31 citations