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August 1, 1961CirculationOpen Access

Some Aspects of Myogenesis in Vitro

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Population

Embryonic chick leg muscle cells in replicate monolayer cultures

Design

Preclinical

Authors

LELudwig W. EichnaState University of New YorkIKIrwin R. KonigsbergNational Institutes of Health

Discussion

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Implication

Challenges DNA synthesis dependence for myotube formation; hypothesis-generating for myoblast fusion mechanisms.

Structured PICO

P
Population
Embryonic chick leg muscle cells in replicate monolayer cultures
I
Intervention
Methyl-bis (betachloroethylamine) (nitrogen mustard)
O
Outcome
Formation of multinuclear cells and nuclear enlargementsurrogate

The study suggests that myoblast proliferation is self-limiting and that multinuclear cell formation in muscle cells does not require ongoing DNA synthesis.

Cite This Study

Eichna et al. (1961) studied this question.

synapsesocial.com/papers/6a82aa818ddd99b9b523a4ffhttps://doi.org/10.1161/01.cir.24.2.447
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Influence of Colchicine on the Form of Skeletal Muscle in Tissue Culture.1953 · 30 citations
  2. 2DIFFERENTIATION IN CULTURE OF MIXED AGGREGATES OF DISSOCIATED TISSUE CELLS1955 · 87 citations