Why the study?
Does an ergonovine test induce coronary artery spasm in patients with atypical chest pain after successful PTCA?
Does an ergonovine test induce coronary artery spasm in patients with atypical chest pain after successful PTCA?
Coronary artery spasm can be induced in a significant proportion of patients with atypical chest pain after successful PTCA, suggesting increased vasomotor tone at the previous stenosis site.
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Spasm induction associated with atypical pain post-PTCA; hypothesis-generating and should not yet change practice.
An ergonovine test (0.2 mg ergonovine i.v.) was performed on 32 consecutive patients showing a good long-term result 3 to 6 months after successful PTCA. In seven patients (22%) a significant spasm could be induced. Six of the seven patients complained of atypical chest pain as compared to two of 25 patients with a negative test. This difference was statistically significant (P less than 0.01). These results implicate that a higher vasomotor tone at the site of previous stenosis is responsible for atypical chest pain in patients after successful PTCA and good angiographic long-term follow-up. The application of long-term nifedipine and nitroglycerin in this patient group seems to be indicated.
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Probst et al. (1988) studied this question.
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