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Increased expression of Bcl-2 protein has been demonstrated in various cancerous and precancerous lesions. The B-cell lymphoma-2 gene is a proto-oncogene that inhibits apoptosis, therefore keeping the cell alive. Bcl-2 Mutations leads to an overexpression of Bcl-2 products leading to apoptosis impairment resulting in neoplastic changes as a consequence. Hence, the objective of the study was to investigate the expression of Bcl-2 in fibro epithelial polyp (FP), oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC).
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Hajar et al. (2023) studied this question.
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