Synthesis of Epothilones: Stereoselective Routes to Epothilone B

All articles of this category In connection with our studies of the total syntheses of epothilones we report our efforts on the syntheses of epothilone B using a macro-lactonization and a metathesis approach. Key reaction for the solution of the acyclic stereoselection is a stereoselective aldol reaction. epothilones - natural products - anti-tumor-activity - aldol reaction - macro-lactonization - metathesis