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October 1, 1993Acta Anaesthesiologica Scandinavica

The independent metabolic effects of halo thane and isoflurane anaesthesia

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Why the study?

Does isoflurane compared to halothane alter metabolic and hormonal responses in healthy women undergoing abdominal hysterectomy?

Population

12 healthy, unpremedicated women scheduled for total abdominal hysterectomy

Comparison

Isoflurane anaesthesia combined with… vs Halothane anaesthesia combined with thiopentone…

Design

Other

Follow-up

3 hours

Authors

FCF. CarliLifeArcGRG RonzoniRadboud University NijmegenJWJ. Matthew WebsterUniversity of Kentucky

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Implication

Anaesthesia may suppress metabolism and stress hormones independently of surgery; Level 5 data leaves open isoflurane-halothane differences in hysterectomy patients.

Structured PICO

Does isoflurane compared to halothane alter metabolic and hormonal responses in healthy women undergoing abdominal hysterectomy?

P
Population
12 healthy, unpremedicated women scheduled for total abdominal hysterectomy
I
Intervention
Isoflurane anaesthesia (1 MAC) combined with thiopentone, pancuronium, and oxygen-enriched air (FiO2 = 34%) for 3 hours
C
Comparator
Halothane anaesthesia (1 MAC) combined with thiopentone, pancuronium, and oxygen-enriched air (FiO2 = 34%) for 3 hours
O
Outcome
Oxygen consumption (VO2), carbon dioxide production (VCO2), circulating concentrations of hormones (insulin, growth hormone, cortisol), metabolites, amino acids, and albuminsurrogate

Anaesthesia with either isoflurane or halothane significantly decreases whole body oxygen consumption and alters hormone and metabolite fluxes independent of surgical stress.

Cite This Study

Carli et al. (1993) studied this question.

synapsesocial.com/papers/6a82adbcfb68d755121c227chttps://doi.org/10.1111/j.1399-6576.1993.tb03787.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The independent metabolic effects of enflurane anaesthesia and surgery1991 · 15 citations
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  3. 3Body Metabolism During General Anesthesia Without Superimposed Surgical Stress1971 · 15 citations
  4. 4PLASMA CORTISOL, CORTICOSTERONE AND NON-PROTEIN-BOUND CORTISOL IN EXTRACORPOREAL CIRCULATION1972 · 20 citations
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