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August 7, 1971BMJOpen Access

Streptokinase in Recent Myocardial Infarction: A Controlled Multicentre Trial

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Why the study?

Does streptokinase reduce mortality and reinfarction compared to heparin in patients with recent myocardial infarction?

Population

764 patients suffering from myocardial infarction of less than 24 hours' duration

Comparison

Streptokinase standardized treatment lasting for… vs Heparin standardized treatment lasting for 24…

Design

RCT, Allocated at random

Follow-up

Average period of six weeks in hospital

Discussion

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Member takes

Overview

Supports streptokinase over heparin in recent MI; confirms mortality benefit in this RCT.

Structured PICO

Does streptokinase reduce mortality and reinfarction compared to heparin in patients with recent myocardial infarction?

P
Population
764 patients suffering from myocardial infarction of less than 24 hours' duration
I
Intervention
Streptokinase standardized treatment lasting for 24 hours
C
Comparator
Heparin standardized treatment lasting for 24 hours
O
Outcome
Total hospital mortalityhard clinical

Streptokinase is superior to heparin in reducing hospital mortality and reinfarction rates in patients with recent myocardial infarction.

Limitations

  • 34 patient charts were rejected because of data failure, including all 28 charts from one centre

Cite This Study

A 1971 study studied this question.

synapsesocial.com/papers/6a82adc3dbeb3f12274404b2https://doi.org/10.1136/bmj.3.5770.325
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