Key result
Simultaneous infusion of heparin and streptokinase significantly shortened mean reperfusion time (57 vs 101 minutes) and reduced infarct size compared to sequential infusion.
Why the study?
Does simultaneous infusion of intravenous heparin during streptokinase improve reperfusion time and reduce infarct size in patients with acute myocardial infarction?
Population
37 consecutive patients with acute myocardial infarction
Comparison
Intravenous heparin infused simultaneously… vs Intravenous heparin infused after streptokinase…
Design
RCT, randomised
Follow-up
short-term (hours)
Authors
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Co-administration of heparin with streptokinase shortens reperfusion and limits infarct size in AMI; extends support for simultaneous anticoagulation during fibrinolysis.
RCT (n=37)
Does simultaneous infusion of intravenous heparin during streptokinase improve reperfusion time and reduce infarct size in patients with acute myocardial infarction?
Absolute Event Rate: 57% vs 101%
Simultaneous administration of intravenous heparin with streptokinase in acute myocardial infarction accelerates reperfusion and reduces infarct size compared to sequential administration.
Melandri et al. (1990) conducted an RCT in Acute myocardial infarction (n=37). Intravenous heparin during streptokinase infusion vs. Intravenous heparin after streptokinase infusion was evaluated on Mean reperfusion time (minutes). Simultaneous infusion of heparin and streptokinase significantly shortened mean reperfusion time (57 vs 101 minutes) and reduced infarct size compared to sequential infusion.
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