Fluorinated Carbohydrates as Lectin Ligands: Versatile Sensors in ¹⁹F‐Detected Saturation Transfer Difference NMR Spectroscopy

As a novel approach for studying carbohydrate-lectin interactions spectroscopically, we combine the resolution and specificity of (19)F-detected NMR spectroscopy with the sensitivity of the saturation transfer difference (STD) technique. The resulting background-free (19)F-STD spectra open a promising perspective for broad application with medical relevance, for example, in drug discovery.