What question did this study set out to answer?

To identify the anatomical distribution, developmental timing, and pathway specificity of retinoic acid-generating aldehyde dehydrogenase in the mouse nervous system.

August 2, 1994Proceedings of the National Academy of SciencesOpen Access

High levels of a retinoic acid-generating dehydrogenase in the meso-telencephalic dopamine system.

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Authors

PMPeter McCafferyUniversity of Aberdeen UDUrsula C. DrägerUniversity of Massachusetts Chan Medical School

Discussion

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Implication

Laboratory study reveals localized retinoic acid-producing dehydrogenase in mouse dopamine pathways, highlighting implications for Parkinson disease transplants and disulfiram neurotoxicity.

Key Points

To identify the anatomical distribution, developmental timing, and pathway specificity of retinoic acid-generating aldehyde dehydrogenase in the mouse nervous system.
Assayed the spatial expression and localization of disulfiram-sensitive class-1 aldehyde dehydrogenase across the mouse brain and adrenal chromaffin cells.
Tracked enzyme expression in relation to tyrosine hydroxylase onset along meso-telencephalic dopaminergic projections during development.
Class-1 aldehyde dehydrogenase localized predominantly to the basal forebrain within axons and terminals of dopaminergic projections spanning from the ventral tegmentum to the corpus striatum and nucleus accumbens shell.
Enzyme expression arose early in development shortly after tyrosine hydroxylase detection, following a rostral-dorsal to ventral gradient in the striatum while remaining absent in other dopaminergic cell groups.

Cite This Study

McCaffery et al. (1994) studied this question.

synapsesocial.com/papers/6a82b1ab040bdabcf346fcfd https://doi.org/10.1073/pnas.91.16.7772

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Implication

Laboratory study reveals localized retinoic acid-producing dehydrogenase in mouse dopamine pathways, highlighting implications for Parkinson disease transplants and disulfiram neurotoxicity.

High levels of a retinoic acid-generating dehydrogenase in the meso-telencephalic dopamine system.

Discussion

Member takes

Implication

Key Points

Cite This Study

High levels of a retinoic acid-generating dehydrogenase in the meso-telencephalic dopamine system.

Discussion

Member takes

Implication

Key Points

Cite This Study

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