Why the study?
Does short-term caloric restriction improve myocardial ischemic tolerance via adiponectin in mice?
Population
Adiponectin antisense transgenic (Ad-AS) mice and wild-type (WT) mice
Comparison
Caloric restriction vs Fed ad libitum
Design
Preclinical, randomly assigned
Follow-up
5 weeks
Authors
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Preclinical findings only; leaves open whether adiponectin-dependent caloric restriction benefits translate to human ischemic tolerance.
Does short-term caloric restriction improve myocardial ischemic tolerance via adiponectin in mice?
Short-term caloric restriction protects the heart from ischemia/reperfusion injury via an adiponectin-AMPK dependent pathway.
Shinmura et al. (2007) studied this question.
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