Key result
Adiponectin deficiency enhanced myocardial apoptosis and infarct size (P<0.01), whereas globular adiponectin administration reversed these effects by reducing oxidative and nitrative stress.
Why the study?
Does administration of the globular domain of adiponectin reduce myocardial ischemia/reperfusion injury and oxidative/nitrative stress in adiponectin-/- mice?
Population
Adiponectin-/- or wild-type mice subjected to 30 minutes of myocardial ischemia followed by 3 hours or 24…
Comparison
Administration of the globular domain of… vs Adiponectin-/- mice without intervention, and…
Design
Preclinical
Follow-up
3 hours or 24 hours
Authors
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Supports globular adiponectin cardioprotection in murine I/R models; hypothesis-generating for human translation.
Does administration of the globular domain of adiponectin reduce myocardial ischemia/reperfusion injury and oxidative/nitrative stress in adiponectin-/- mice?
p-value: p=<0.01
Adiponectin protects the heart from ischemia/reperfusion injury by inhibiting iNOS and NADPH oxidase protein expression, thereby reducing oxidative and nitrative stress.
Tao et al. (2007) studied Myocardial ischemia/reperfusion injury. Globular domain of adiponectin vs. Wild-type mice was evaluated on Myocardial infarct size and apoptosis (p=<0.01). Adiponectin deficiency enhanced myocardial apoptosis and infarct size (P<0.01), whereas globular adiponectin administration reversed these effects by reducing oxidative and nitrative stress.
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