Why the study?
Does intracoronary administration of adiponectin reduce myocardial ischemia-reperfusion injury in a pig model?
Population
Pig model of myocardial ischemia-reperfusion injury
Design
Preclinical
Follow-up
24 hours
Authors
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Should not change clinical practice; leaves open whether intracoronary adiponectin confers human cardioprotection after I/R.
Does intracoronary administration of adiponectin reduce myocardial ischemia-reperfusion injury in a pig model?
Intracoronary adiponectin reduces myocardial infarct size and improves left ventricular function in a pig model of ischemia-reperfusion injury by suppressing inflammation, apoptosis, and oxidative stress.
Kondo et al. (2010) studied this question.
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