Alterations in Regional Pulmonary Blood Flow in Mitral Valve Disease Studied by Radioisotope Scanning
Why the study?
Does external scintillation scanning with 131 I-MAA detect abnormalities in regional pulmonary blood flow in patients with mitral valve disease compared to normal subjects?
Population
48 subjects, comprising 35 patients with mitral valve disease and 13 normal subjects.
Comparison
External scintillation scanning of intravenously… vs Normal subjects.
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Supports noninvasive LA pressure estimation in mitral valve disease; leaves open validation against modern imaging before clinical use.
Structured PICO
Does external scintillation scanning with 131 I-MAA detect abnormalities in regional pulmonary blood flow in patients with mitral valve disease compared to normal subjects?
P
Population
48 subjects, comprising 35 patients with mitral valve disease and 13 normal subjects.
I
Intervention
External scintillation scanning of intravenously injected 131 I-labeled macroaggregates of human serum albumin (131 I-MAA).
C
Comparator
Normal subjects.
O
Outcome
Ratio of concentration of radioactivity per unit of lung volume in the upper third of the right lung to that in the lower third (U/L).surrogate
External scintillation scanning with 131 I-MAA demonstrates that pulmonary blood flow distribution is altered in mitral valve disease and correlates with left atrial pressure.
Cite This Study
Friedman et al. (1966) studied this question.