We present techniques for bridging the gap between idealized inverse covariance weighted quadratic estimation of 21 cm power spectra and the real-world challenges presented universally by interferometric observation. By carefully evaluating various estimators and adapting our techniques for large but incomplete data sets, we develop a robust power spectrum estimation framework that preserves the so-called "Epoch of Reionization (EoR) window" and keeps track of estimator errors and covariances. We apply our method to observations from the 32-tile prototype of the Murchinson Widefield Array to demonstrate the importance of a judicious analysis technique. Lastly, we apply our method to investigate the dependence of the clean EoR window on frequency---especially the frequency dependence of the so-called ``wedge" feature---and establish upper limits on the power spectrum from $z=6.2$ to $z=11.7$. Our lowest limit is Δ(k)<0.3 Kelvin at 95% confidence at a comoving scale k=0.046 Mpc^-1 and $z=9.5$.
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Dillon et al. (2014) studied this question.
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