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July 31, 2009Proceedings of the National Academy of SciencesOpen Access

The repeat domain of the melanosome fibril protein Pmel17 forms the amyloid core promoting melanin synthesis

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RMRyan P. McGlincheyFSFrank ShewmakerPMPeter McPhie

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McGlinchey et al. (2009) studied this question.

synapsesocial.com/papers/6a82b42cc40fc255ce133d98https://doi.org/10.1073/pnas.0906509106
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  1. 1Amyloids protect the silkmoth oocyte and embryo2000 · 197 citations
  2. 2A melanocyte-specific gene, Pmel 17, maps near the silver coat color locus on mouse chromosome 10 and is in a syntenic region on human chromosome 12.1991 · 158 citations
  3. 3Propagating structure of Alzheimer’s β-amyloid (10–35) is parallel β-sheet with residues in exact register1998 · 392 citations
  4. 4THE SILVER MOUSE1930 · 48 citations
  5. 5Premelanosome Amyloid-like Fibrils Are Composed of Only Golgi-processed Forms of Pmel17 That Have Been Proteolytically Processed in Endosomes2007 · 79 citations