August 10, 2012Journal of Biological ChemistryOpen Access

Cell Surface Expression of Human Ether-a-go-go-related Gene (hERG) Channels Is Regulated by Caveolin-3 Protein via the Ubiquitin Ligase Nedd4-2

View Full Paper

Ask AI

Bookmark

Population

Cultured neonatal rat ventricular myocytes and cells expressing hERG channels

Design

Preclinical

Authors

TWTingzhong WangElectrophysiology XLXian LiBinzhou Medical University HSHeidi Shallow

Discussion

Member takes

Implication

Cav3-Nedd4-2 interaction may reduce native I(Kr) in rat myocytes; hypothesis-generating for hERG regulation and requires in vivo validation.

Structured PICO

Population

Cultured neonatal rat ventricular myocytes and cells expressing hERG channels

Intervention

Expression of Caveolin-3 (Cav3), mutation of Nedd4-2 interaction sites, or siRNA knockdown of endogenous Cav3 or Nedd4-2

Outcome

hERG expression levels at the plasma membrane and whole cell current amplitude (I(Kr))surrogate

Caveolin-3 regulates the cell surface expression and degradation of hERG channels via the ubiquitin ligase Nedd4-2, highlighting a novel molecular mechanism in cardiac electrophysiology.

Cite This Study

Wang et al. (2012) studied this question.

synapsesocial.com/papers/6a82b46984489985200f66aa https://doi.org/10.1074/jbc.m112.389643

View Full Paper

Ask AI

Bookmark

Implication

Cav3-Nedd4-2 interaction may reduce native I(Kr) in rat myocytes; hypothesis-generating for hERG regulation and requires in vivo validation.

Cell Surface Expression of Human Ether-a-go-go-related Gene (hERG) Channels Is Regulated by Caveolin-3 Protein via the Ubiquitin Ligase Nedd4-2

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cell Surface Expression of Human Ether-a-go-go-related Gene (hERG) Channels Is Regulated by Caveolin-3 Protein via the Ubiquitin Ligase Nedd4-2

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider