July 7, 2010Journal of Biological ChemistryOpen Access

Involvement of Caveolin in Low K+-induced Endocytic Degradation of Cell-surface Human Ether-a-go-go-related Gene (hERG) Channels

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Population

HEK 293 cells stably expressing hERG channels and cultured neonatal rat ventricular myocytes

Comparison

Low extracellular K+ conditions, with… vs Normal K+ conditions or control cells without…

Design

Preclinical

Authors

HMHamid MassaeliUniversity of Ottawa TSTao SunShandong University XLXian LiXihua University

Discussion

Member takes

Implication

Does not support immediate practice changes; leaves open caveolin targeting for hypokalemia-related LQTS.

Structured PICO

Population

HEK 293 cells stably expressing hERG channels and cultured neonatal rat ventricular myocytes

Intervention

Low extracellular K+ conditions (0 mM K+), with manipulation of Caveolin-1, Caveolin-3, and dynamin 2 expression

Comparator

Normal K+ conditions or control cells without genetic manipulation

Outcome

Degradation and internalization of mature hERG channels and reduction of I(Kr)surrogate

A caveolin-dependent endocytic route is involved in low extracellular potassium-induced degradation of mature hERG channels, providing mechanistic insight into hypokalemia-exacerbated long QT syndrome.

Cite This Study

Massaeli et al. (2010) studied this question.

synapsesocial.com/papers/6a82b46984489985200f66ac https://doi.org/10.1074/jbc.m110.124909

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Involvement of Caveolin in Low K+-induced Endocytic Degradation of Cell-surface Human Ether-a-go-go-related Gene (hERG) Channels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Involvement of Caveolin in Low K+-induced Endocytic Degradation of Cell-surface Human Ether-a-go-go-related Gene (hERG) Channels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider