Why the study?
Does monoubiquitination mediate endocytic degradation of mature hERG channels under low K+ conditions in hERG-HEK cells?
Population
hERG-expressing human embryonic kidney (HEK) 293 stable cell line (hERG-HEK cells)
Comparison
Low K+ conditions with various genetic… vs Normal K+ conditions and control cells
Design
Preclinical
Authors
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Offers mechanistic insight into hypokalemia-induced IKr reduction; leaves open whether ubiquitination pathways alter arrhythmia risk in vivo.
Does monoubiquitination mediate endocytic degradation of mature hERG channels under low K+ conditions in hERG-HEK cells?
Monoubiquitination dynamically mediates the endocytic degradation of mature hERG channels under low K+ conditions, providing mechanistic insight into hypokalemia-induced reduction of IKr and potential arrhythmias.
Sun et al. (2010) studied this question.
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