Population
Rat isolated aorta segments (with and without endothelium)
Comparison
Endothelium-dependent vasodilators, direct… vs Tissues without endothelium (endothelium-denuded)
Design
Preclinical
Follow-up
120 minutes
Authors
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Animal findings on endothelial cGMP require clinical caution; leaves open human translation and mechanistic trials.
The endothelium plays a major role in enhancing the release and accumulation of cyclic GMP from rat aortic tissue, both basally and upon stimulation.
Schini et al. (1989) studied this question.
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