The angiotensinogen gene locus is implicated in the genetic basis of human essential hypertension, supported by both animal models and human population studies.
Answers are grounded in this paper and cite their sources.
Angiotensinogen locus merits prioritized genetic research in hypertension; leaves open any clinical translation or risk stratification.
The candidacy of angiotensinogen for a role in the genetic basis of hypertension is supported by the observation that plasma angiotensinogen levels track with raised blood pressure through families. In addition, transgenic mice with overexpression of a rat angiotensinogen gene develop hypertension, and knockout mice with a disrupted gene and absent angiotensinogen production develop low blood pressure. There are now two studies in populations of white European origin and one in African Caribbeans providing support for a role of the angiotensinogen gene locus in human essential hypertension.
No takes yet. Share an insight, caveat, or question.
Caulfield et al. (1996) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: