Why the study?
Does amlodipine improve blood pressure normalization and reduce adverse events compared to nitrendipine in patients with mild to moderate essential hypertension?
Population
74 patients with mild to moderate essential hypertension
Comparison
Amlodipine monotherapy vs Nitrendipine monotherapy
Design
Other, open
Follow-up
4 weeks
Authors
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Amlodipine may be preferable for tolerability in mild hypertension; leaves open whether superiority holds in larger randomized trials.
Does amlodipine improve blood pressure normalization and reduce adverse events compared to nitrendipine in patients with mild to moderate essential hypertension?
Amlodipine provides comparable antihypertensive efficacy to nitrendipine but with a better safety and tolerability profile in patients with mild to moderate essential hypertension.
Englert et al. (1991) studied this question.
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