Why the study?
Does amlodipine improve blood pressure normalization and safety compared to nitrendipine in patients with mild to moderate essential hypertension?
Population
74 patients (43 male, 31 female) with mild to moderate essential hypertension
Comparison
Amlodipine monotherapy vs Nitrendipine monotherapy
Design
Cohort, Open-label
Follow-up
4 weeks
Authors
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May support amlodipine preference for tolerability; observational data leave comparative efficacy open for randomized confirmation.
Does amlodipine improve blood pressure normalization and safety compared to nitrendipine in patients with mild to moderate essential hypertension?
Amlodipine and nitrendipine have comparable antihypertensive efficacy, but amlodipine is associated with fewer adverse effects in patients with mild to moderate hypertension.
Englert et al. (1991) studied this question.
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