Population
Rat hepatoma cell line McA RH7777
Comparison
Transfection with human apoE3 cDNA and infection… vs Control McA RH7777 cells
Design
Preclinical
Authors
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Highlights species differences in HDL regulation; leaves open clinical relevance for apoE-targeted therapies.
Expression of human apoE in rat hepatocytes alters the composition of secreted HDL particles, displacing endogenous rat apoA-I and apoE.
Reardon et al. (1998) studied this question.
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