What question did this study set out to answer?

To evaluate global differences in diabetes prevalence and diagnosis when using fasting plasma glucose versus hemoglobin A1c across diverse world regions.

November 1, 2023Nature MedicineOpen Access

Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c

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To evaluate global differences in diabetes prevalence and diagnosis when using fasting plasma glucose versus hemoglobin A1c across diverse world regions.
Analyzed pooled data from 117 population-based health examination surveys across multiple global regions.
Developed mathematical prediction equations to estimate the probability of elevated HbA1c given specific FPG values and vice versa in individuals without previously diagnosed diabetes.
Previously undiagnosed diabetes detected via screening ranged from 30% of total diabetes cases in high-income western regions to 66% in south Asia.
Only 29% to 39% of screen-detected individuals across regions had concordant elevation of both FPG and HbA1c, while the remainder showed discordant elevations.
Isolated elevated HbA1c was more prevalent than isolated elevated FPG in most low- and middle-income regions, indicating that relying solely on FPG underestimates diabetes prevalence.

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Implication

Cross-sectional study demonstrates global discordance between fasting glucose and hemoglobin A1c, highlighting that single-test screening underestimates diabetes prevalence.

Cite This Study

Zhou et al. (2023) studied this question.

synapsesocial.com/papers/6a82b73ce0918b5470d119f0 https://doi.org/10.1038/s41591-023-02610-2

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Implication

Cross-sectional study demonstrates global discordance between fasting glucose and hemoglobin A1c, highlighting that single-test screening underestimates diabetes prevalence.

Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c

Key Points

Discussion

Implication

Cite This Study

Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c

Key Points

Discussion

Implication

Cite This Study

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