May 31, 2019Diabetes Care
Predictive Value of Fasting Glucose, Postload Glucose, and Hemoglobin A1c on Risk of Diabetes and Complications in Chinese Adults
Why the study?
Uncertainty remains regarding the predictive value of various glycemic measures for the risk of diabetes and its complications.
Do fasting plasma glucose, 2-h postload glucose, and HbA1c independently predict the risk of incident diabetes, cardiovascular disease, cancer, and mortality in Chinese adults aged ≥40 years?
Population
193,846 adults aged ≥40 years in China
Comparison
Fasting plasma glucose vs 2-h postload glucose vs HbA1c
Design
Population-based cohort study
Follow-up
Up to 5 years
Authors
Discussion
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Implication
May improve risk stratification for CVD, cancer, and mortality beyond FPG and HbA1c; leaves open whether 2h-PG screening changes outcomes.
Structured PICO
Do fasting plasma glucose, 2-h postload glucose, and HbA1c independently predict the risk of incident diabetes, cardiovascular disease, cancer, and mortality in Chinese adults aged ≥40 years?
P
Population
193,846 adults aged ≥40 years from a population-based cohort in China
I
Intervention
Assessment of fasting plasma glucose (FPG), 2-h postload glucose (2h-PG), and HbA1c
C
Comparator
Comparison across different glycemic categories (normal, prediabetes, untreated diabetes based on ADA 2010 criteria)
O
Outcome
Incident diabetes, cardiovascular disease (CVD), cancer, and mortality at up to 5 years follow-uphard clinical
2-hour postload glucose is an independent predictor of incident diabetes, cardiovascular disease, cancer, and mortality, improving risk prediction beyond fasting plasma glucose and HbA1c.
Cite This Study
Lu et al. (2019) studied this question.