Why the study?
Does OPN-305 reduce infarct size and preserve cardiac function in a porcine model of ischemia/reperfusion injury?
Population
Pigs (n=38) undergoing 75 minutes of ischemia followed by 24 hours of reperfusion
Comparison
OPN-305 at 12.5, 6.25, or 1.56 mg/kg infused… vs Saline infused intravenously 15 minutes before…
Design
Preclinical
Follow-up
24 hours
Authors
Loading...
Supports TLR2 blockade as adjunct in AMI; hypothesis-generating in porcine model and requires human trials.
Does OPN-305 reduce infarct size and preserve cardiac function in a porcine model of ischemia/reperfusion injury?
In a large-animal porcine model of ischemia/reperfusion injury, the humanized anti-TLR2 antibody OPN-305 significantly reduced infarct size and preserved cardiac function, suggesting potential as an adjunctive therapy for acute myocardial infarction.
Arslan et al. (2012) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: