Population
Wild-type and iNOS-deficient mice
Comparison
Lipopolysaccharide 20 mg/kg intraperitoneal… vs Vehicle injection
Design
Preclinical
Follow-up
12 hours
Authors
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iNOS may mediate endotoxin-induced vascular hyporeactivity in mice; hypothesis-generating for targeted human sepsis therapies.
This study provides direct evidence that iNOS mediates the impairment of vascular contraction following LPS treatment.
Gunnett et al. (1998) studied this question.
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