July 29, 2003Molecular Biology of the CellOpen Access

Localization of a Class III Myosin to Filopodia Tips in Transfected HeLa Cells Requires an Actin-binding Site in its Tail Domain

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Population

HeLa cells

Design

Preclinical

Authors

FEF. Les EricksonSalisbury University ACAmoreena C. CorsaGilead Sciences (United States)ADAndrea C. DoséUniversity of North Carolina at Charlotte

Discussion

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Implication

Elucidates Myo3A targeting in filopodia; extends cytoskeletal models and leaves open in vivo validation.

Structured PICO

Population

HeLa cells

Intervention

Transfection with GFP-Myo3A fusion constructs (wild-type, motor active site mutation, and deletion mutants)

Outcome

Cellular localization of Myo3A (specifically to filopodia tips)

Demonstrates that class III myosin localization to filopodia tips depends on both its motor activity and a specific actin-binding motif in its tail domain.

Cite This Study

Erickson et al. (2003) studied this question.

synapsesocial.com/papers/6a82bc6c8ddd99b9b523aa49 https://doi.org/10.1091/mbc.e02-10-0656

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Localization of a Class III Myosin to Filopodia Tips in Transfected HeLa Cells Requires an Actin-binding Site in its Tail Domain

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Localization of a Class III Myosin to Filopodia Tips in Transfected HeLa Cells Requires an Actin-binding Site in its Tail Domain

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider