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October 4, 2006Journal of NeuroscienceOpen Access

A New Compartment at Stereocilia Tips Defined by Spatial and Temporal Patterns of Myosin IIIa Expression

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Population

Preclinical model studying stereocilia maturation and myosin IIIa localization

Design

Preclinical

Authors

MSMark E. SchneiderUniversity of PennsylvaniaADAndrea C. DoséUniversity of North Carolina at CharlotteFSFelipe T. SallesNational Institutes of Health

Discussion

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Implication

Should not yet change clinical practice in hearing loss; hypothesis-generating for myosin IIIa targeting in stereocilia disorders.

Structured PICO

P
Population
Preclinical model studying stereocilia maturation and myosin IIIa localization
I
Intervention
Overexpression of deletion mutants for functional domains of green fluorescent protein (GFP)-myosin IIIa
O
Outcome
Localization of myosin IIIa and effect on stereocilia shape (elongation and bulging)

Identifies a novel molecular compartment at the distal end of stereocilia defined by myosin IIIa, which influences stereocilia shape and is implicated in hearing loss.

Cite This Study

Schneider et al. (2006) studied this question.

synapsesocial.com/papers/6a70c15ae5469ee92be16f8dhttps://doi.org/10.1523/jneurosci.2812-06.2006
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Myosin 3A transgene expression produces abnormal actin filament bundles in transgenicXenopus laevisrod photoreceptors2004 · 25 citations
  2. 2Identification of Myosin III as a Protein Kinase1996 · 46 citations
  3. 3Molecular characterization of a novel human PDZ domain protein with homology to INAD from Drosophila melanogaster1997 · 58 citations
  4. 4High-resolution structure of hair-cell tip links2000 · 319 citations
  5. 5Localization of Myosin-Iβ near Both Ends of Tip Links in Frog Saccular Hair Cells1998 · 94 citations