Effect of Streptokinase on Hemostasis
Population
Rabbit mesentery model
Comparison
Streptokinase vs Control animals
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Streptokinase effects on hemostatic plugs differ by route in animals; hypothesis-generating but should not change clinical practice.
Structured PICO
P
Population
Rabbit mesentery model
I
Intervention
Streptokinase (systemic infusion or topical application)
C
Comparator
Control animals
O
Outcome
Hemostatic plug formation and dissolutionsurrogate
Streptokinase impairs hemostatic plug formation by digesting fibrin as it forms around aggregated platelets, without altering platelet aggregation directly.
Cite This Study
Hirsh et al. (1968) studied this question.