Why the study?
Does overexpression of CuZn-SOD or Mn-SOD prevent NO-mediated inhibition of NOS III in endothelial cells?
Population
Endothelial cells (ECs)
Comparison
Adenoviral overexpression of copper-zinc… vs Cells infected with an adenovirus expressing…
Design
Preclinical
Authors
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CuZn-SOD may protect endothelial NOS III in oxidative stress models; leaves open translation to human cardiovascular therapies.
Does overexpression of CuZn-SOD or Mn-SOD prevent NO-mediated inhibition of NOS III in endothelial cells?
Overexpression of CuZn-SOD protects endothelial NOS III from NO-mediated inhibition by scavenging superoxide and reducing peroxynitrite generation.
Brennan et al. (2002) studied this question.
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