Why the study?
Does nitric oxide exposure inhibit endothelial NOS activity in cultured pulmonary arterial endothelial cells?
Population
cultured pulmonary arterial endothelial cells
Comparison
Nitric oxide exposure via Sodium nitroprusside… vs Untreated cells (implied)
Design
Preclinical
Authors
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May implicate superoxide in nitric oxide-induced eNOS inhibition; leaves open its role in rebound pulmonary hypertension after inhaled NO.
Does nitric oxide exposure inhibit endothelial NOS activity in cultured pulmonary arterial endothelial cells?
Nitric oxide exposure inhibits eNOS activity via superoxide generation, providing a potential mechanism for rebound pulmonary hypertension after withdrawal of inhaled NO therapy.
Sheehy et al. (1998) studied this question.
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