Why the study?
Does altered nitric oxide availability affect pulmonary vascular tone at rest and during exercise in adult sheep?
Population
Adult sheep weighing 20-35 kg
Comparison
N omega-nitro-L-arginine 20 mg/kg IV, L-arginine… vs Control runs without intervention (baseline)
Design
Preclinical, random order for dose response
Follow-up
Acute (up to 4 minutes of exercise)
Authors
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NO maintains basal pulmonary tone at rest in sheep but not exercise vasodilation; leaves open translation to human physiology.
Does altered nitric oxide availability affect pulmonary vascular tone at rest and during exercise in adult sheep?
Endogenous nitric oxide maintains low basal pulmonary vascular tone at rest but does not mediate the characteristic exercise-induced pulmonary vasodilation in sheep.
Koizumi et al. (1994) studied this question.
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