February 1, 1986Journal of Clinical InvestigationOpen Access

A variant primary structure of apolipoprotein C-II in individuals of African descent.

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Population

4 patients of African ancestry with hypertriglyceridemia and eruptive or pedunculated xanthomata, their…

Design

Cross-sectional

Authors

HMH J MenzelUniversity of California, San Francisco JKJohn P. KaneBrigham Young University MMMary J. MalloyUniversity of California, San Francisco

Discussion

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Implication

ApoC-II2 variant shows ancestry-specific distribution; leaves open its role in hypertriglyceridemia and requires functional studies before clinical relevance.

Structured PICO

Population

4 patients of African ancestry with hypertriglyceridemia and eruptive or pedunculated xanthomata, their first-degree relatives, 50 normolipidemic blacks, and 500 Caucasian subjects with hyperlipidemia.

Outcome

Presence and structural characterization of apolipoprotein C-II isoformssurrogate

Identified a genetic polymorphism of apolipoprotein C-II specific to individuals of African descent, though its effect on hyperlipemia development remains unknown.

Cite This Study

Menzel et al. (1986) studied this question.

synapsesocial.com/papers/6a82c1fee41271e79b8d60ef https://doi.org/10.1172/jci112342

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Implication

ApoC-II2 variant shows ancestry-specific distribution; leaves open its role in hypertriglyceridemia and requires functional studies before clinical relevance.

A variant primary structure of apolipoprotein C-II in individuals of African descent.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A variant primary structure of apolipoprotein C-II in individuals of African descent.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider